Photo of Melissa Brindise

Melissa Brindise

Assistant Professor


  • Mechanical Engineering

301B Reber Building


Research Website

Research Areas:

Biomedical/Bioengineering; Experimental Fluid Dynamics; Thermal/Fluid Sciences

Interest Areas:

Cardiovascular flows: flow in cerebral aneurysms, traumatic brain injury (TBI), cognition, heart disease; experimental fluid mechanics; transition to turbulence in pulsatile flows; automated methods development





Journal Articles

  • Sandy Karam, Nikhil Shirdade, Benjamin Madden, Justin Rheinstadter, Ephraim Church, Melissa Brindise and Guha Manogharan, 2023, "Additive manufacturing of patient-specific high-fidelity and thickness-controlled cerebral aneurysm geometries", Manufacturing Letters, 35, pp. 770-777
  • Melissa Brindise, Keving Buno, Luis Solorio and Pavlos Vlachos, 2023, "Automated Layer Identification for Skin Tissue Histology Images", Annals of Biomedical Engineering, 51, (2), pp. 443-455
  • Jiacheng Zhang, Sean Rothenberger, Melissa Brindise, Michael Markl, Vitaliy Rayz and Pavlos Vlachos, 2022, "Wall Shear Stress Estimation for 4D Flow MRI Using Navier-Stokes Equation Correction", Annals of Biomedical Engineering, pp. 1-16
  • Brett Meyers, Melissa Brindise, Shelby Kutty and Pavlos Vlachos, 2022, "A method of direct estimation of left ventricular global longitudinal strain rate from echocardiograms", Scientific Reports, 12, (1), pp. 1-11
  • Jiacheng Zhang, Melissa Brindise, Sean Rothenberger, Michael Markl, Vitaliy Rayz and Pavlos Vlachos, 2022, "A multi-modality approach for enhancing 4D flow magnetic resonance imaging via sparse representation", Royal Society Interface, 19, (186), pp. 202110751
  • Melissa Brindise, Brett Meyers, Shelby Kutty and Pavlos Vlachos, 2021, "Automated peak prominence-based iterative Dijkstras algorithm for segmentation of B-mode echocardiograms", IEEE Transactions of Biomedical Engineering, 69, (5), pp. 1595-1607
  • Jiacheng Zhang, Sean M. Rothenberger, Melissa Brindise, M. B. Scott, H. Berhane, J. J. Baraboo, Michael Markl, V. L. Rayz and Pavlos P. Vlachos, 2021, "Divergence-free constrained phase unwrapping and Denoising for 4D flow MRI using weighted least squares", IEEE Transactions on Medical Imaging, 40, (12), pp. 3389-3399
  • Melissa Brindise, Brett A. Meyers and Pavlos Vlachos, 2020, "Universality of vortex ring decay in the left ventricle", Journal of Biomechanics, 103, pp. 109695
  • Jiacheng Zhang, Melissa Brindise, Sean Rothenberger, S. Schnell, M. Markl, D. Saloner, V. L. Rayz and Pavlos P. Vlachos, 2019, "4D Flow MRI Pressure Estimation using Velocity Measurement-Error based Weighted Least-Squares", IEEE Transactions on Medical Imaging, 39, (5), pp. 1668-1680
  • Melissa Brindise, Sean Rothenberger, B. Dickerhoff, S. Schnell, M. Markl, D. Saloner, V. L. Rayz and Pavlos P. Vlachos, 2019, "Multi-modality cerebral aneurysm haemodynamic analysis: in vivo 4D Flow MRI, in vitro particle velocimetry, and in silico computational fluid dynamics", Journal of the Royal Society Interface, 16, (158), pp. 20190465
  • Melissa Brindise, Margaret Busse and Pavlos Vlachos, 2018, "Density- and viscosity-matched Newtonian and non-Newtonian blood-analog solutions with PDMS refractive index", Experiments in Fluids, 59, (11), pp. 1-8
  • Melissa Brindise and Pavlos Vlachos, 2018, "Pulsatile pipe flow transition: Flow waveform effects", Physics in Fluids, 30, (1), pp. 015111
  • Melissa Brindise and Pavlos Vlachos, 2017, "Proper Orthogonal Decomposition Truncation Method for Data Denoising and Order Reduction", Experiments in Fluids, 58, (4), pp. 1-18
  • Melissa Brindise, Claudio Chiastra, Francesco Burzotta, Francesco Migliavacca and Pavlos Vlachos, 2017, "Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: An In Vitro Study", Annals of Biomedical Engineering, 45, (3), pp. 542-553

Research Projects

  • February 2024 - January 2027, "Characterizing Transition to Turbulence in Pulsatile Pipe Flow," (Sponsor: National Science Foundation).
  • April 2022 - March 2025, "Evaluating the effect of transient inflow waveforms in cerebral aneurysms," (Sponsor: American Heart Association).

Honors and Awards


Service to Penn State:

Service to External Organizations:




With more than 60 faculty members, 330 graduate students, and 1,000 undergraduate students, the Penn State Department of Mechanical Engineering embraces a culture that welcomes individuals with a diversity of backgrounds and expertise. Our faculty and students are innovating today what will impact tomorrow’s solutions to meeting our energy needs, homeland security, biomedical devices, and transportation systems. We offer B.S. degrees in mechanical engineering as well as resident (M.S., Ph.D.) and online (M.S.) graduate degrees in mechanical engineering. See how we’re inspiring change and impacting tomorrow at

Department of Mechanical Engineering

137 Reber Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-865-2519